Targeting bile acids and lipotoxicity for NASH treatment
نویسندگان
چکیده
منابع مشابه
Targeting bile acids and lipotoxicity for NASH treatment
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting approximately 20%-30% of the population in Western countries. Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD that can develop into cirrhosis and hepatocellular carcinoma (HCC). However, the underlying mechanism of progression of steatosis to NASH and cirrhosis is poorly understood....
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The first objectives of this article are to review the structure, chemistry, and physiology of bile acids and the types of bile acid malabsorption observed in clinical practice. The second major theme addresses the classical or known properties of bile acids, such as the role of bile acid sequestration in the treatment of hyperlipidemia; the use of ursodeoxycholic acid in therapeutics, from tra...
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Bear bile has been included in Asian pharmacopeias for thousands of years in treatment of several diseases, ranging from sore throat to hemorrhoids. The hydrophilic bile acids tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) are the major bile acids of bear bile. Both of these are available as synthetic formulations and are approved by the health administrations of several coun...
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چکیده ندارد.
15 صفحه اولBile acids and bile alcohols of bullfrog1
Gallbladder bile of the bullfrog, R a m catesbezana was found to contain a number of minor bile acids and bile alcohols in unconjugated forms. The following bile acids and bile alcohols were identified by combined gas-liquid chromatography-mass spectrometry: cholic acid, allocholic acid, 3a,7a, 12a-trihydroxy-5a-cholestan-26-oic acid, 3a,7a, 12atrihydroxy-24-methyl-5~-cholestan-26-oic acid, 3a,...
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ژورنال
عنوان ژورنال: Hepatology Communications
سال: 2017
ISSN: 2471-254X
DOI: 10.1002/hep4.1127